ARA-290

ARA-290 — Tissue-Protective Erythropoietin-Derived Peptide

ARA-290 is a synthetic peptide derived from the non-haematopoietic region of erythropoietin (EPO), specifically engineered to selectively activate the innate repair receptor (IRR) without engaging the classical erythropoietin receptor responsible for red blood cell production. This selective activation profile makes ARA-290 a valuable research tool for investigating tissue-protective and anti-inflammatory mechanisms in controlled experimental settings.

Research Applications

Research involving ARA-290 has centred on its capacity to modulate inflammatory signalling, promote neural repair, and attenuate neuropathic pain in preclinical models. Studies have examined its role in activating the IRR on macrophages and other immune cells, resulting in a shift towards anti-inflammatory cytokine profiles and reduced tissue damage. Investigators have also explored its influence on peripheral nerve regeneration, metabolic tissue protection, and cellular survival under ischaemic or inflammatory stress conditions.

Formulation & Purity

Supplied as a high-purity white lyophilised powder, this product exceeds >99% purity as verified by HPLC analysis. Its freeze-dried formulation ensures long-term structural stability, maintaining peptide integrity throughout storage and transport. Researchers may reconstitute the compound using bacteriostatic water or a sterile diluent suited to their experimental protocol.

Intended Use

ARA-290 is intended exclusively for in vitro and non-clinical scientific research. It is not approved for human or animal therapeutic, diagnostic, or medicinal use. All handling and experimentation must be conducted by trained professionals within appropriate controlled laboratory environments.

Ultima Labs